Guadalajara (GDL) to Des Moines (DSM): 1,558 miles (2,507 km) great-circle, about 3h 35m nonstop by our estimate. Cheapest fare observed: $553 round-trip on Viva Aerobus, with 3 stops, departing May 16, 2026.
$553 round-trip, Viva Aerobus VB3196, departing 2026-05-16 at 19:45, returning 2026-06-05. The recorded itinerary left on a Saturday, returning on a Friday 20 nights later; the fare was observed 21 days before departure. "Book this flight" opens Kiwi.com with the same airline and dates.
At $553, it ranked 19th of the 30 round-trip fares we recorded from GDL (median $427). That is 35.5 cents per great-circle mile (round-trip price over one-way distance), above the GDL median of 25.3 cents across 30 round-trip routes.
Routes from GDL of similar length: Fort Lauderdale (1,516 mi) at $647 and Reno (1,634 mi) at $485.
Viva Aerobus had the cheapest fare on 9 of 30 GDL routes. It is the 17th longest of the 30 routes we track from GDL.
That depends on your passport and trip, so check the official source for United States: U.S. Customs and Border Protection: international visitors. Connecting elsewhere? Check that country's transit rules too.
Travelpayouts fares (cheapest per route, observed April 25, 2026); OurAirports coordinates and elevations; IANA zones America/Mexico_City, America/Chicago; flight time is our estimate.