Portland (PDX) to Louisville (SDF): 1,946 miles (3,131 km) great-circle, about 4h 25m nonstop by our estimate. Cheapest fare observed: $335 round-trip on American Airlines, with 1 stop, departing May 19, 2026.
$335 round-trip, American Airlines AA2519, departing 2026-05-19 at 11:56, returning 2026-06-02. The recorded itinerary left on a Tuesday, returning on a Tuesday 14 nights later; the fare was observed 24 days before departure. "Book this flight" opens Kiwi.com with the same airline and dates.
At $335, it ranked 13th of the 30 round-trip fares we recorded from PDX (median $378). That is 17.2 cents per great-circle mile (round-trip price over one-way distance), below the PDX median of 21.2 cents across 30 round-trip routes.
Routes from PDX of similar length: Indianapolis (1,872 mi) at $387 and Houston (1,842 mi) at $249.
American Airlines had the cheapest fare on 5 of 30 PDX routes. It is the 18th longest of the 30 routes we track from PDX.
Of 2 departure airports with a fare to Louisville, Portland (PDX) ranked 2nd at $335. Lowest: $328 from Denver (DEN); highest: $335 from Portland (PDX); 1 nonstop. Cheapest-fare airlines (routes): American Airlines (1) and United Airlines (1).
Travelpayouts fares (cheapest per route, observed April 25, 2026); OurAirports coordinates and elevations; IANA zones America/Los_Angeles, America/Kentucky/Louisville; flight time is our estimate.