Panama City (PTY) to Indianapolis (IND): 2,160 miles (3,476 km) great-circle, about 4h 50m nonstop by our estimate. Cheapest fare observed: $639 round-trip on Copa, with 1 stop, departing May 23, 2026.
$639 round-trip, Copa CM432, departing 2026-05-23 at 21:33, returning 2026-05-30. The recorded itinerary left on a Saturday, returning on a Saturday 7 nights later; the fare was observed 28 days before departure. "Book this flight" opens Kiwi.com with the same airline and dates.
At $639, it ranked 18th of the 30 round-trip fares we recorded from PTY (median $593). That is 29.6 cents per great-circle mile (round-trip price over one-way distance), close to the PTY median of 31.9 cents across 30 round-trip routes.
Routes from PTY of similar length: New York (2,208 mi) at $517 and Antofagasta (2,326 mi) at $661.
Copa had the cheapest fare on 14 of 30 PTY routes. It is the 13th longest of the 30 routes we track from PTY.
Of 7 departure airports with a fare to Indianapolis, Panama City (PTY) ranked 7th at $639. Lowest: $219 from Orlando (MCO); highest: $639 from Panama City (PTY); 0 nonstop. Cheapest-fare airlines (routes): Frontier (3), American Airlines (1), Copa (1), Southwest (1) and Spirit (1).
That depends on your passport and trip, so check the official source for United States: U.S. Customs and Border Protection: international visitors. Connecting elsewhere? Check that country's transit rules too.
Travelpayouts fares (cheapest per route, observed April 25, 2026); OurAirports coordinates and elevations; IANA zones America/Panama, America/New_York; flight time is our estimate.