Panama City (PTY) to Mexico City (MEX): 1,498 miles (2,411 km) great-circle, about 3h 30m nonstop by our estimate. Cheapest fare observed: $385 round-trip on Aeromexico, nonstop, departing June 6, 2026.
$385 round-trip, Aeromexico AM465, departing 2026-06-06 at 15:00, returning 2026-07-07. The recorded itinerary left on a Saturday, returning on a Tuesday 31 nights later; the fare was observed 42 days before departure. "Book this flight" opens Kiwi.com with the same airline and dates.
At $385, it ranked 6th of the 30 round-trip fares we recorded from PTY (median $593). That is 25.7 cents per great-circle mile (round-trip price over one-way distance), below the PTY median of 31.9 cents across 30 round-trip routes.
Routes from PTY of similar length: Lima (1,466 mi) at $498 and Bridgetown (1,376 mi) at $463.
Aeromexico had the cheapest fare on 3 of 30 PTY routes. It is the 17th longest of the 30 routes we track from PTY.
Of 24 departure airports with a fare to Mexico City, Panama City (PTY) ranked 15th at $385. Lowest: $73 from Guadalajara (GDL); highest: $1375 from Addis Ababa (ADD); 13 nonstop. Cheapest-fare airlines (routes): Volaris (6), Viva Aerobus (5), Aeromexico (4), Arajet (2), Copa (1) and Ethiopian (1), plus 5 more.
That depends on your passport and trip, so check the official source for Mexico: Instituto Nacional de Migracion (Mexico). Connecting elsewhere? Check that country's transit rules too.
Travelpayouts fares (cheapest per route, observed April 25, 2026); OurAirports coordinates and elevations; IANA zones America/Panama, America/Mexico_City; flight time is our estimate.